2-Acetoxy-2-phenylacetyl chloride
2-Acetoxy-2-phenylacetyl chloride
CAS: 1638-63-7
Molecular Formula: C10H9ClO3
2-Acetoxy-2-phenylacetyl chloride - Names and Identifiers
2-Acetoxy-2-phenylacetyl chloride - Physico-chemical Properties
| Molecular Formula | C10H9ClO3 |
| Molar Mass | 212.63 |
| Density | 0.943 g/mL at 25 °C(lit.) |
| Melting Point | 36°C |
| Boling Point | 125-130 °C10 mm Hg(lit.) |
| Flash Point | >230 °F |
| Storage Condition | 0-6°C |
| Refractive Index | n20/D 1.514(lit.) |
| Physical and Chemical Properties | The boiling point of commodities with chemical purity above 95% is 125-130 ℃(1.33kPa), the relative density is 0.943, the refractive index is 1.5140, and the flash point is> 110 ℃. |
| Use | Uses: pharmaceutical intermediates for semi-synthesis or total synthesis of post-atropine hydrobromide. |
2-Acetoxy-2-phenylacetyl chloride - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29173995 |
| Hazard Class | 8 |
| Packing Group | III |
2-Acetoxy-2-phenylacetyl chloride - Upstream Downstream Industry
| Raw Materials | Thionyl chloride Acetyl chloride Sulfur dioxide (S)-(+)-O-Acetyl-L-mandelic acid |
| Downstream Products | ACETYLHOMATROPINE |
2-Acetoxy-2-phenylacetyl chloride - Production method
Acetylmandelic acid is obtained by the acetylation reaction of mandelic acid, which is then obtained by chlorination. In the dry reflux device, acetylmandelic acid (about 1.29 parts) equivalent to 1 part of mandelic acid acetylated is placed. Add 2.38 parts of dichlorosulfoxide and react at 60-65 ℃ for 2.5h to release hydrogen chloride and sulfur dioxide gas. Then the temperature is raised to 60-70 ℃, and the excess dichlorosulfoxide is recovered under reduced pressure. Add 1.8 times the amount of anhydrous benzene, vacuum azeotropic distillation, and evaporate excess dichlorosulfoxide and acetyl chloride, until the distillation temperature gradually rises to 80 ℃, and when there is no benzene distillation, add 1.2 times the amount of anhydrous benzene, and then distillation once under reduced pressure until the distillation temperature gradually rises to 90 ℃. Get a light yellow oil, that is, acetylmandelyl chloride. The yield is about 1.44 times that of mandelic acid.
Last Update：2024-04-10 22:29:15
2-Acetoxy-2-phenylacetyl chloride - Nature
| Specific gravity | 0.943 |
| NIST chemical information | Acetylmandelic chloride(1638-63-7) |
Last Update：2024-04-09 21:04:16
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Raw Materials for 2-Acetoxy-2-phenylacetyl chloride
Downstream Products for 2-Acetoxy-2-phenylacetyl chloride